Chromatography is a valuable tool for chemists, which has found use in clinical, academic, and industrial settings. In order to ensure accurate and reproducible results while conducting research, it is imperative that chromatographic systems are functioning properly. As chromatographic systems become more sophisticated and include more components, suitability testing of entire chromatography systems (e.g. not simply individual parts such as a column) is important to prevent inaccurate data due to uncalibrated, miscalibrated, malfunctioning, broken, or worn out components, as well as drift or improper settings. Examples of components found in a chromatography system include the column, tubing, mobile phase composition, computer hardware, software, injector, pump, in-line filter, guard column, detector, and temperature control apparatus, as well as combinations thereof. Examples of systems that these components can be used with include liquid chromatography (LC), high performance liquid chromatography (HPLC), ultra high performance liquid chromatography (UHPLC), supercritical fluid chromatography (SFC), and carbon dioxide based chromatography.